Based on consistent evidence from observational studies of a very strong risk reduction of colorectal cancer (CRC) incidence and mortality following endoscopic screening examinations (sigmoidoscopy, colonoscopy), these are now included in many expert screening recommendations.1,2 However, there is ongoing debate regarding the optimal age, time intervals, and number of screening examinations. This particularly applies to colonoscopy, which is more effective than other screening modalities at decreasing CRC-related incidence and mortality. The recent study of Sonnenberg and Delcò3 comparing the cost-effectiveness of 2 screening programs based on a single or repeated colonoscopy makes a valuable contribution to this ongoing debate.
Brenner H, Arndt V, Stürmer T. Cost-effectiveness of Colonoscopy in Screening for Colorectal Cancer. Arch Intern Med. 2002;162(19):2249. doi: