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Editor's Correspondence
November 11, 2002

Statin Use and Fracture Risk—Reply

Arch Intern Med. 2002;162(20):2379-2380. doi:

In reply

As Seeger and Choi have pointed out, pravastatin does not share the in vitro effect of other statins on bone morphogenetic protein-2 production.1 Subgroup analysis of data from the Geelong Osteoporosis Study2 for pravastatin alone was not performed because the subsample size was too small for statistical analysis. From a group of 69 statin users, 10 used pravastatin (3 from the fracture group and 7 from the nonfracture group). However, the original data set has been reanalyzed with pravastatin users excluded, and results are presented in Table 1.

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