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Editor's Correspondence
November 11, 2002

Falls and 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors

Arch Intern Med. 2002;162(20):2381. doi:

In a recent issue of the ARCHIVES,1 we reported lower fracture risk among women taking 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) for hypercholesterolemia. The research was prompted by the finding that statins increase bone morphogenetic protein-2, leading to osteoblast differentiation and bone formation.2 The substantial 60% reduction in fracture risk we reported persisted after adjusting for potential confounders and was greater than expected from increases observed in bone mineral density alone.

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