We thank Dr Caracciolo and colleagues for allowing us to address issues that limitations of space prevented in an article focused primarily on drug interactions in the treatment of hypertension.1 They are, of course, correct in their assertion that ethnicity and sex can influence antihypertensive therapeutics. One must remember, however, that the influence ethnicity and sex wield is relatively weak compared with the effects that individual pharmacogenetic changes can potentially bring to bear, since groups defined by ethnicity and by sex are inevitably mixtures of a large number of specific genetic variants.
Flockhart DA, Dos Santos JE. Ethnic, Racial, and Sex-Specific Factors Are Important in Cardiovascular Pharmacotherapeutics—Reply. Arch Intern Med. 2002;162(21):2494. doi: