We read with great interest the article by Wang et al1 regarding the effects of smoking on the biochemical picture of patients with hepatitis C virus (HCV) infection and its implications for preventing disease progression. In their study, Wang and colleagues clearly showed that smoking in anti-HCV–positive subjects is independently associated with elevated alanine aminotransferase (ALT) levels.
Giannini E, Testa R. Can Changing Counseling Strategy Change the Picture of the Chronic Hepatitis C Patient Population?. Arch Intern Med. 2002;162(21):2497. doi: