Clinical Observation
January 13, 2003

Celecoxib-Related Renal Papillary Necrosis

Author Affiliations

From the Department of Internal Medicine, Section on Rheumatology, Ochsner Clinic Foundation, New Orleans, La.


Copyright 2003 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2003

Arch Intern Med. 2003;163(1):114-115. doi:10.1001/archinte.163.1.114

Selective cyclooxygenase 2 (COX-2) inhibitors are known to affect renal prostaglandins (epoprostenol and dinoprostone), which are at least in part COX-2 dependent. Consequently, adverse events including hypertension, peripheral edema, hypercalemia, hyponatremia, and acute renal failure have been reported to occur with the new COX-2–specific inhibitors. This case report posits celecoxib as a likely cause of renal papillary necrosis and alerts physicians to the possibility of this additional renal complication with COX-2–specific inhibitors.