Selective cyclooxygenase 2 (COX-2) inhibitors are known to affect renal prostaglandins (epoprostenol and dinoprostone), which are at least in part COX-2 dependent. Consequently, adverse events including hypertension, peripheral edema, hypercalemia, hyponatremia, and acute renal failure have been reported to occur with the new COX-2–specific inhibitors. This case report posits celecoxib as a likely cause of renal papillary necrosis and alerts physicians to the possibility of this additional renal complication with COX-2–specific inhibitors.
Akhund L, Quinet RJ, Ishaq S. Celecoxib-Related Renal Papillary Necrosis. Arch Intern Med. 2003;163(1):114-115. doi:10.1001/archinte.163.1.114