We read with interest the excellent article by Kruip and colleagues1 regarding the use of D-dimer assays to distinguish between patients who may have pulmonary embolism from those who do not. In their investigation, plasma D-dimer concentration was measured with a quantitative rapid enzyme-linked immunosorbent D-dimer assay (VIDAS DD; bioMérieux, Inc, Paris, France). The authors state that the sensitivity of the assay was 98% (95% confidence interval, 90%-100%) and the negative predictive value (NPV) was 99% (95% confidence interval, 95%-100%).
Caine GJ, Lip GYH. D-Dimer Tests for Assessment of Patients With Suspected Pulmonary Embolism. Arch Intern Med. 2003;163(2):243. doi:10.1001/archinte.163.2.243