Curhan et al1 report an increased risk of hypertension with use of NSAIDs in younger women based on an analysis of data collected from participants in the Nurses' Health Study II. Our experience in a recently completed double-blind randomized controlled trial of NSAID therapy for Alzheimer disease (unpublished data, 2003) provides evidence of risk of hypertension in older individuals.
Aisen PS, Schafer K, Grundman M, Thomas R, Thal LJ. NSAIDs and Hypertension. Arch Intern Med. 2003;163(9):1115. doi:10.1001/archinte.163.9.1115-a