The role of stress in the development of hypertension remains controversial.1,2 We cannot exclude the possibility raised by Glaser that increased analgesic use may be observed among individuals who experience stress. However, women take analgesics for other indications as well, such as menstrual cramps and musculoskeletal pain. Because of the known physiological effects of analgesics, it is likely that analgesics may be directly involved in the development of hypertension.
Curhan GC, Stampfer MJ. NSAIDs and Hypertension—Reply. Arch Intern Med. 2003;163(9):1115-1116. doi:10.1001/archinte.163.9.1115-a