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An alternative message can perhaps be derived from the article by Meyer et al.1 The article documents that INR was outside therapeutic range in 59% of patients receiving warfarin. The inference is that appropriate levels of anticoagulation control were not achieved in almost half. Is this acceptable? Is there a problem with the paradigm or is medication potency undependable?
Rothschild BM. Apparent Warfarin Potency Inconsistencies Compromise Effectiveness. Arch Intern Med. 2003;163(10):1243. doi:10.1001/archinte.163.10.1243-a