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Editor's Correspondence
June 23, 2003

Thalidomide Has Activity in Treating Complex Regional Pain Syndrome

Arch Intern Med. 2003;163(12):1487-1488. doi:10.1001/archinte.163.12.1487

Rajkumar et al1 reported that thalidomide (Thalomid; Celgene Corporation; Warren, NJ), prescribed for newly diagnosed multiple myeloma, led to unexpected improvement and near resolution of reflex sympathetic dystrophy in a woman with a 3-year history of the disorder. We report on our recent clinical experience using thalidomide to treat reflex sympathetic dystrophy, better known as complex regional pain syndrome (CRPS). This disorder is characterized by neuropathic pain, allodynia, edema, autonomic dysfunction, disordered movements, dystrophy, and atrophy.2

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