Knockaert et al have made some very insightful comments that highlight the complexity of FUO and how the paucity of good evidence has resulted in a lack of consensus. We have attempted to provide an approach and guidance for the evaluation of such patients using existing evidence.1
A thorough history review and physical examination impact pretest probabilities and may direct physicians to tests that do not conform to our proposed algorithm. Knockaert et al have identified potential diagnostic clues as one way of influencing clinical judgment and guiding testing. We agree that one must not ignore the art of medicine, but it should not be divorced from the science.
Mourad O, Palda V, Detsky AS. An Evidence-Based Approach to Fever of Unknown Origin—Reply. Arch Intern Med. 2003;163(16):1976-1978. doi:10.1001/archinte.163.16.1976-a