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Editor's Correspondence
January 12, 2004

Obesity and Alzheimer Disease: Roles of Diet and Genetics

Author Affiliations

Copyright 2004 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2004

Arch Intern Med. 2004;164(1):109-110. doi:10.1001/archinte.164.1.109-b

The recent article reporting that being overweight is a risk factor for Alzheimer disease (AD) for women1 is consistent with the growing body of literature on the link between diet and AD.27 The primary dietary risk factors are total caloric intake and saturated fat intake,2,4,5,7 while cereals and fish are important risk reduction factors.2,5,6 Cholesterol is also a risk factor.8 It has also been suggested that caloric restriction would reduce the risk of AD.3 In addition, the presence of the APOE ϵ4 allele, the "thrifty gene," greatly increases the risk of AD for a high-risk diet.5

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