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Editor's Correspondence
October 11, 2004

Chronic Fatigue Syndrome, Pregnancy, and Addison Disease

Arch Intern Med. 2004;164(18):No Pagination Specified. doi:10.1001/archinte.164.18.2065-a

Schacterle and Komaroff1 found that the rate of spontaneous abortions was nearly 4 times higher (30% vs 8%) in the pregnancies that occurred after the onset of chronic fatigue syndrome (CFS) compared with those that occurred before its onset. In light of the results of a Danish survey2 that reported an increased risk of spontaneous abortion with increasing maternal age, Schacterle and Komaroff1 argue that their findings could be explained by the fact that the mean ± SD age of those who became pregnant before the onset of CFS was 24.8 ± 4.3 years, whereas it was 33.0 ± 4.5 years for those who became pregnant after that onset. However, if we compare these ranges of maternal ages with similar ranges (25-29 years and 35-39 years) found in the Danish study,2 it is clear that the nearly 4-fold higher rate mentioned above is significantly greater than the approximate 2-fold higher rate (24.6% vs 11.9%) of spontaneous abortions reported in older Danish women.2

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