In their article recently published in the ARCHIVES, Torn and colleagues1 underscore the importance to establish an optimal therapeutic range for people taking warfarin. Warfarin, in fact, is associated with a high risk of bleeding when the international normalized ratio rises above the upper limits and with a lacking prophylactic effect when it falls under the lower limits of the therapeutic range. To encompass these problems, a strict control performed by experienced personnel in anticoagulant (AC) clinics and the use of computer-assisted dosage adjustment are recommended in the editorial by O’Donnel and Hirsh2 in the same ARCHIVES issue.
Bellelli G, Rozzini R, Trabucchi M. Establishing an Optimal Therapeutic Range for Coumarins. Arch Intern Med. 2004;164(20):2281-2283. doi:10.1001/archinte.164.20.2282-a