In Reply We wish to thank van der Meer and colleagues for their interest in our work.1 We fully agree that a comparison of the prevalence of chest pain characteristics (CPCs) in women with that in men would not be of major help to clinicians. Therefore, one of the most important novel findings of our analysis was the comparison of the prevalence of CPCs in women with acute myocardial infarction (AMI) with the prevalence of CPCs in women with a final diagnosis other than AMI. As also stated by van der Meer and colleagues, that is the question asked by clinicians. The answer to that question is provided by displaying the likelihood ratios for each CPC individually for women and men in Figure 1 and Table 3 in our article.1 In addition, to determine if some CPCs help to better differentiate women with AMI from women with other final diagnosis as they do in men, Figure 1 and Table 3 in our article1 display the P value for interaction to show whether some of the CPCs provide sex-specific diagnostic information for the detection of AMI.
Rubini Gimenez M, Twerenbold R, Mueller C. Sex-Specific Chest Pain Characteristics—Reply. JAMA Intern Med. 2015;175(4):650. doi:10.1001/jamainternmed.2014.8075