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Editor's Correspondence
July 27, 2009

Cost-effectiveness of Tuberculosis Screening in Health Care Workers Is Not Robust—Reply

Arch Intern Med. 2009;169(14):1336-1340. doi:10.1001/archinternmed.2009.212

In reply

We appreciate the opportunity to respond to the thoughtful comments of Mancuso and colleagues concerning new data on the test characteristics of interferon gamma release assays (IGRAs) published after our cost-effectiveness analysis article1 was accepted for publication. Mancuso and colleagues express concern that the latest meta-analysis by Pai and colleagues2 reported a pooled sensitivity of 77% for the TST vs our pooled value of 67%; 78% for the QuantiFERON-TB Gold (QFT-G) (Cellestis Limited) vs our value of 83%; and 70% for the QFT-GIT vs our value of 76%.1,2

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