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Invited Commentary
July 12, 2010

Adverse Drug Responses: An Increasing Threat to the Well-being of Older PatientsComment on “Development and Validation of a Score to Assess Risk of Adverse Drug Reactions Among In-Hospital Patients 65 Years or Older”

Author Affiliations

Author Affiliations: Leonard Davis School of Gerontology and Keck School of Medicine, University of Southern California, Los Angeles, and the Los Angeles Jewish Home for the Aging, Reseda, California (Dr Schneider); and Division of Nephrology, Department of Medicine, Keck School of Medicine (Dr Campese).

Arch Intern Med. 2010;170(13):1148-1149. doi:10.1001/archinternmed.2010.186

The article by Onder et al is a valuable tool for clinicians to assess the risk of adverse drug responses (ADRs) in an older population. It also is timely because the incidence of ADRs is increasing rapidly. The ADRs that were reported to the Food and Drug Administration increased 160% from 34 966 in 1998 to 89 842 in 2005.1 During this period, fatal ADRs increased 170% from 5519 to 15 107.1 The older population has a disproportionately high percentage of ADRs for several reasons: the increasing number of older persons, the greater comorbidity seen with aging, and the increased use of medications by physicians treating older patients.

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