Invited Commentary
July 12, 2010

Moving Toward Personalization of Colorectal Cancer ScreeningComment on “Influence of Race and Sex on Prevalence and Recurrence of Colon Polyps”

Author Affiliations

Author Affiliations: Department of Medicine, NorthShore University HealthSystem, University of Chicago Pritzker School of Medicine, Chicago, Illinois.


Copyright 2010 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2010

Arch Intern Med. 2010;170(13):1132-1134. doi:10.1001/archinternmed.2010.206

Widespread use of colonoscopy has achieved a modicum of success, as evidenced by a slight decrease in CRC rates. However, a recent National Institutes of Health consensus panel noted that screening rates are still suboptimal, and thus colorectal malignant neoplasms remain the second leading cause of cancer deaths.1 Moreover, performing colonoscopy on the entire average-risk population (approximately 100 million Americans 50 years or older) is remarkably inefficient, with a low yield of clinically significant neoplasia (approximately 5%-6%).2 Thus, from a cancer prevention perspective, most screening colonoscopies are unproductive.

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