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Invited Commentary
November 08, 2010

Physical Activity, Weight, Diet, and Breast Cancer Risk ReductionComment on “Physical Activity and Risk of Breast Cancer Among Postmenopausal Women”

Author Affiliations

Author Affiliation: Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.

Arch Intern Med. 2010;170(20):1792-1793. doi:10.1001/archinternmed.2010.416

Since a seminal prospective cohort study showing reduced breast cancer risk in physically active women1 13 years ago and my commentary2 calling for a broader research agenda in this area, more than 5 dozen studies have reported on the association of physical activity with breast cancer risk. The prospective cohort studies in postmenopausal women have shown a modest (approximately 10%-20%) but statistically significant association of reduced risk of breast cancer in women who engage in the equivalent of 3 h/wk of moderate-level physical activity or greater, ie, who meet or exceed the current recommendations for US adults.3 The associations have been confirmed consistently enough that the US Department of Health and Human Services Physical Activity Guidelines Advisory Committee concluded in 2008 that strong evidence demonstrates that, compared with less active persons, more active women have lower rates of breast cancer.3

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