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Invited Commentary
January 10, 2011

The Bundled Approach to MRSA Surgical Site Infection Prevention: Is the Whole Greater Than the Sum of Its Parts?Comment on “Sustained Reduction in Methicillin-Resistant Staphylococcus aureus Wound Infections After Cardiothoracic Surgery”

Author Affiliations

Author Affiliation: Division of Infectious Diseases, University of California, San Francisco.

Arch Intern Med. 2011;171(1):73-74. doi:10.1001/archinternmed.2010.448

Surgical site infections (SSIs) cause significant patient morbidity and mortality and add $10 billion annually to health care expenditures.1Staphylococcus aureus is the most common pathogen, with methicillin-resistant S aureus (MRSA) accounting for up to 65% of poststernotomy mediastinitis.2 Compared with infections due to methicillin-susceptible S aureus (MSSA), MRSA has been associated with increased mortality, treatment failure, length of hospital stay, and costs.3,4

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