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Episodes of hypoglycemia are particularly dangerous in the older population. To reduce the risk of hypoglycemia, relaxation of the standard hemoglobin A1c (HbA1c) goals has been proposed for frail elderly patients. However, the risk of hypoglycemia in this population with higher HbA1c levels is unknown.
Patients 69 years or older with HbA1C values of 8% or greater were evaluated with blinded continuous glucose monitoring for 3 days.
Forty adults (mean [SD] age, 75  years; HbA1C value, 9.3% [1.3%]; diabetes duration, 22  years; 28 patients [70%] with type 2 diabetes mellitus; and 37 [93%] using insulin) were evaluated. Twenty-six patients (65%) experienced 1 or more episodes of hypoglycemia (glucose level <70 mg/dL). Among these, 12 (46%) experienced a glucose level below 50 mg/dL and 19 (73%), a level below 60 mg/dL. The average number of episodes was 4; average duration, 46 minutes. Eighteen patients (69%) had at least 1 nocturnal episode (10 PM to 6 AM). Of the total of 102 hypoglycemic episodes, 95 (93%) were unrecognized by finger-stick glucose measurements performed 4 times a day or by symptoms.
Hypoglycemic episodes are common in older adults with poor glycemic control. Raising HbA1C goals may not be adequate to prevent hypoglycemia in this population.
Munshi MN, Segal AR, Suhl E, Staum E, Desrochers L, Sternthal A, Giusti J, McCartney R, Lee Y, Bonsignore P, Weinger K. Frequent Hypoglycemia Among Elderly Patients With Poor Glycemic Control. Arch Intern Med. 2011;171(4):362-364. doi:10.1001/archinternmed.2010.539