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Invited Commentary
March 14, 2011

The Difficult Task of Finding the Best Antihypertensive AgentComment on “Antihypertensive Treatment and Development of Heart Failure in Hypertension”

Author Affiliations

Author Affiliation: Department of Cardiology, Angiology, and Pulmonology, University of Heidelberg, Heidelberg, Germany.


Copyright 2011 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2011

Arch Intern Med. 2011;171(5):394-365. doi:10.1001/archinternmed.2010.414

There are a few silent epidemics in medicine, and heart failure certainly is one of them. There are good reasons to care about it: End-stage HF is more deadly than most cancers, and only recently has the idea of HF with preserved ejection fraction been transformed into being accepted as diastolic heart failure. Now diastolic HF is interesting for 2 reasons: (1) it is more common in women—a subgroup notoriously underdiagnosed, undertreated, and underrepresented in clinical trials; and (2) from a global perspective, one of the major risk factors for its development is hypertension and the ensuing hypertensive heart disease. Hypertension, however, does not only lead to diastolic HF but, from a global perspective, it represents the major risk factor for the development of HF as such.1

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