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Invited Commentary
ONLINE FIRST
June 13, 2011

Opportunities to Decrease Inappropriate Uses of Proton Pump InhibitorsComment on “Proton Pump Inhibitor Use and the Antifracture Efficacy of Alendronate”

Author Affiliations

Author Affiliation: Los Angeles Department of Public Health, Los Angeles, California.

Arch Intern Med. 2011;171(11):1004-1005. doi:10.1001/archinternmed.2011.21

The May 2010 issue of the Archives included 3 articles on the harms of PPIs: Gray et al1 showed that PPIs were associated with an increase in the rate of spine, lower arm, and total fractures; Howell et al2 showed that PPIs increased the risk of Clostridium difficile infection; and Linsky et al3 showed that PPIs also increased the recurrence of C difficile infection. We deliberately grouped these articles together because we wanted to draw attention to the adverse effects of these drugs given data showing that 53% to 69% of PPI prescriptions are for inappropriate indications.46

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