Invited Commentary
June 13, 2011

Opportunities to Decrease Inappropriate Uses of Proton Pump InhibitorsComment on “Proton Pump Inhibitor Use and the Antifracture Efficacy of Alendronate”

Author Affiliations

Author Affiliation: Los Angeles Department of Public Health, Los Angeles, California.


Copyright 2011 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2011

Arch Intern Med. 2011;171(11):1004-1005. doi:10.1001/archinternmed.2011.21

The May 2010 issue of the Archives included 3 articles on the harms of PPIs: Gray et al1 showed that PPIs were associated with an increase in the rate of spine, lower arm, and total fractures; Howell et al2 showed that PPIs increased the risk of Clostridium difficile infection; and Linsky et al3 showed that PPIs also increased the recurrence of C difficile infection. We deliberately grouped these articles together because we wanted to draw attention to the adverse effects of these drugs given data showing that 53% to 69% of PPI prescriptions are for inappropriate indications.46

First Page Preview View Large
First page PDF preview
First page PDF preview