In Reply Advances in medical care depend on well-controlled randomized clinical trials to validate the safety and efficacy of new interventions and to ensure that clinicians understand the active components.1 Hyperbaric oxygen (HBO) treatment is a very time-consuming and costly procedure that is not without harmful effects. Nevertheless, HBO treatment is being promoted by clinicians who dispense the service as a treatment for a vast number of medical conditions for which there are no US Food and Drug Administration indications or even acceptance by respected organizations, such as the Undersea and Hyperbaric Medical Society.2 The field suffers from numerous studies, such as the one by Mukherjee et al,3 that involve observational, nonblinded, nonrandomized methodology.
Hoge CW, Jonas WB. Hyperbaric Oxygen Treatment for Persistent Postconcussion Symptoms—Reply. JAMA Intern Med. 2015;175(7):1241. doi:10.1001/jamainternmed.2015.1051