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Comment & Response
September 2015

Prescription Opioid Duration of Action and the Risk of Unintentional Overdose

Author Affiliations
  • 1Department of Anesthesiology, Louisiana State University Health Science Center, New Orleans
  • 2Department of Anesthesiology and Pain Medicine, University of Washington Medical Center, Seattle
JAMA Intern Med. 2015;175(9):1582-1583. doi:10.1001/jamainternmed.2015.3256

To the Editor It is with great interest that we read the article “Prescription Opioid Duration of Action and the Risk of Unintentional Overdose Among Patients Receiving Opioid Therapy” published in the April issue of JAMA Internal Medicine.1 Miller and colleagues used data from the Veterans Administration Healthcare system and found that patients initiating opioid therapy with long-acting opioids were more than twice as likely to overdose compared with those initiating therapy with short-acting opioids.

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