A woman in her 70s with a history of metastatic renal cell carcinoma presented with nonbloody, watery diarrhea with a frequency of 12 to 15 bowel movements per day and mild abdominal cramps. She was afebrile and had a white blood cell count of 13.7/μL (13 700 × 109/L). She had experienced multiple episodes of diarrhea over the past 2 years. Numerous stool studies during this period were positive on polymerase chain reaction (PCR) assay for Clostridium difficile toxin B gene. Results from repeated testing for C difficile were again positive.
Matta SK, Greenberg A, Singh A. Diarrhea With Clostridium difficile–Positive Stool—Trick or TreatA Teachable Moment. JAMA Intern Med. 2015;175(11):1746-1747. doi:10.1001/jamainternmed.2015.4792