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Comment & Response
October 2015

Study Design for Vitamin D Randomized Clinical Trials

Author Affiliations
  • 1School of Medicine and Pharmacology, The University of Western Australia, Nedlands Western Australia
  • 2School of Public Health, University of Sydney, Westmead, New South Wales, Australia
  • 3School of Clinical Sciences, Faculty of Medicine, Nursing, and Health Sciences, Monash University, Clayton, Victoria, Australia

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JAMA Intern Med. 2015;175(10):1720. doi:10.1001/jamainternmed.2015.3765

To the Editor The article by Uusi-Rasi and colleagues1 raises important considerations in the study design of randomized clinical trials on the effect of vitamin D on falling. It is clear from many randomized clinical trials that the role of vitamin D supplementation on falling—if it has a role—is likely to be found in subsets of the falling population.2 It is unfortunate that the study design did not take advantage of previous study findings.

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