To the Editor LeBlanc and Chou1 updated the US Preventive Services Task Force (USPSTF) review of vitamin D supplements and falls with the trial by Uusi-Rasi and colleagues,2 concluding that vitamin D supplements reduce falls by 11%. However, their meta-analysis incorrectly includes 2 trials of active vitamin D metabolites (Dukas et al, 2004; Gallagher et al, 2001)3,4 that should not be pooled with trials of vitamin D supplements. When these 2 trials are excluded from the meta-analysis, the relative risk of a fall with vitamin D in 9 trials with 5056 participants is 0.91 (CI, 0.83-1.00), a result that is of questionable clinical significance.
Bolland MJ, Grey A, Reid IR. Vitamin D Supplements and the Risk of Falls. JAMA Intern Med. 2015;175(10):1723-1724. doi:10.1001/jamainternmed.2015.3962