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To the Editor The observations by Orlich et al1 on vegetarianism and lower rates of colorectal cancer are consistent with meta-analyses on meat and colorectal cancer.2 Orlich et al offer a mechanism through adiposity and hyperinsulinemia. The Scottish Health and Ethnicity Linkage Study findings may aid interpretation.3
Bhopal RS. Diet and Colorectal Cancer Incidence. JAMA Intern Med. 2015;175(10):1726-1727. doi:10.1001/jamainternmed.2015.4016