Views 1,150
Citations 0
Research Letter
January 2016

Recurrence and Mortality in Young Women With Myocardial Infarction or Ischemic StrokeLong-term Follow-up of the Risk of Arterial Thrombosis in Relation to Oral Contraceptives (RATIO) Study

Author Affiliations
  • 1Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands
  • 2Angelo Bianchi Bonomi Hemophilia and Thrombosis Centre, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milano, Milan, Italy
  • 3Center for Stroke Research Berlin, Charité Universitätsmedizin Berlin, Berlin, Germany
  • 4Brain Center Rudolph Magnus, Department of Neurology and Neurosurgery, University Medical Center Utrecht, Utrecht, the Netherlands
  • 5Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands
  • 6Department of Thrombosis and Haemostasis, Leiden University Medical Center, Leiden, the Netherlands

Copyright 2016 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.

JAMA Intern Med. 2016;176(1):134-136. doi:10.1001/jamainternmed.2015.6523

Rates of death in the acute phase of cardiovascular events have decreased, but disease burden remains high in the increasing number of survivors.1 This finding is particularly important for those affected at a young age.2 Nevertheless, little information is available on the long-term outcome of young patients who survived a cardiovascular event, especially women. Single disease cohorts have suggested that the risk of cardiovascular disease is driven by recurrence of the index event, but, to our knowledge, this has never been investigated in a single study with multiple index groups. We determined the long-term mortality and subtype-specific morbidity in young women surviving myocardial infarction (MI) or ischemic stroke (IS) compared with a control group.

First Page Preview View Large
First page PDF preview
First page PDF preview