In Reply Monticciolo and Morris question the value of our study and generally view the balance of the benefits vs harms of mammography screening as a settled issue. We view the evidence as evolving, a perspective supported by the recent decision of the American Cancer Society to reduce their recommendations for screening. We performed our study1 because the benefits and harms of screening could have evolved since prior randomized trials.
Harding C, Pompei F, Wilson R. Unreliable Conclusions of Breast Cancer Screening, Incidence, and Mortality—Reply. JAMA Intern Med. 2016;176(1):141-142. doi:10.1001/jamainternmed.2015.7207