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Invited Commentary
February 2016

Obesity, Fitness, Hypertension, and PrognosisIs Physical Activity the Common Denominator?

Author Affiliations
  • 1Department of Cardiology, Ochsner Medical Center, New Orleans, Louisiana
  • 2Department of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute, New Orleans, Louisiana
  • 3Ochsner Clinical School, The University of Queensland School of Medicine, New Orleans, Louisiana
  • 4The Office of Energetics, Nutrition Obesity Research Center, University of Alabama at Birmingham
JAMA Intern Med. 2016;176(2):217-218. doi:10.1001/jamainternmed.2015.7571

Obesity has many adverse effects on cardiovascular risk factors, such as dyslipidemia, metabolic syndrome or type 2 diabetes mellitus, and hypertension, as well as on cardiovascular structure and function. Therefore, it is not surprising that the prevalence of cardiovascular diseases is markedly increased in the setting of overweight and obesity.1 Considering that increased fat accumulation causes increases in total blood volume, stroke volume, and cardiac output, it is expected that obesity markedly increases the prevalence of hypertension and places a heavy strain on the left and right sides of the heart, which not surprisingly increases the prevalence of heart failure, even in a setting of metabolically healthy obesity.1

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