Copyright 2016 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
Prescription opioid abuse is a major public health problem in the United States.1 The opioid analgesic hydrocodone bitartrate, traditionally available in combination with nonopioid analgesics, is one of the most commonly abused opioids.2 In 2011, hydrocodone combination analgesic products were involved in almost 100 000 abuse-related emergency department visits in the United States, more than double the number in 2004.3
Jones CM, Lurie PG, Throckmorton DC. Effect of US Drug Enforcement Administration’s Rescheduling of Hydrocodone Combination Analgesic Products on Opioid Analgesic Prescribing. JAMA Intern Med. 2016;176(3):399-402. doi:10.1001/jamainternmed.2015.7799