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Comment & Response
February 2016

Proposed Guidelines for Future Vitamin D Studies

Author Affiliations
  • 1Division of Rheumatology, Department of Internal Medicine, Uludag University, Bursa, Turkey
  • 2Division of Geriatrics, Department of Internal Medicine, Istanbul University, Istanbul, Turkey
JAMA Intern Med. 2016;176(2):280. doi:10.1001/jamainternmed.2015.7971

To the Editor We read with interest the article by Hansen et al1 suggesting that neither low-dose nor high-dose cholecalciferol have beneficial effects on bone or muscle health. We have comments about this well-designed and well-performed study.

First, as the authors underlined, secondary hyperparathyroidism (SH) occurs in only 10% to 33% of people with vitamin D insufficiency and subjects without SH might not benefit from vitamin D treatment. Although the authors did not report the rate of SH in their study, median vitamin D and parathyroid hormone levels indicate that SH was infrequent in these patients. Thus, this study may be considered a contribution to the growing body of evidence indicating that supplementing what is sufficient is not beneficial, if not harmful.24

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