[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.158.119.60. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Views 224
Citations 0
Comment & Response
February 2016

Proposed Guidelines for Future Vitamin D Studies

Author Affiliations
  • 1Division of Rheumatology, Department of Internal Medicine, Uludag University, Bursa, Turkey
  • 2Division of Geriatrics, Department of Internal Medicine, Istanbul University, Istanbul, Turkey
JAMA Intern Med. 2016;176(2):280. doi:10.1001/jamainternmed.2015.7971

To the Editor We read with interest the article by Hansen et al1 suggesting that neither low-dose nor high-dose cholecalciferol have beneficial effects on bone or muscle health. We have comments about this well-designed and well-performed study.

First, as the authors underlined, secondary hyperparathyroidism (SH) occurs in only 10% to 33% of people with vitamin D insufficiency and subjects without SH might not benefit from vitamin D treatment. Although the authors did not report the rate of SH in their study, median vitamin D and parathyroid hormone levels indicate that SH was infrequent in these patients. Thus, this study may be considered a contribution to the growing body of evidence indicating that supplementing what is sufficient is not beneficial, if not harmful.24

First Page Preview View Large
First page PDF preview
First page PDF preview
×