In Reply I am so glad to see these responses to my previously published first-person account1 of the consequences of over-testing. Good and colleagues beautifully highlight the critical importance of considering pretest probability when deciding to order, and how to interpret, a test. As a practicing physician, I use the principle of the Bayes theorem in my decision making more than I understood how to do as a medical student, in part because its logic has allowed me to trust in the veracity of my own negative test result and quell the emotional effect of the initial (likely false-) positive result. I am grateful to Good and colleagues for the explicit reminder of this principle’s importance.
O’Brien M. Finding the Balance of Less is More—Reply. JAMA Intern Med. 2016;176(2):283. doi:10.1001/jamainternmed.2015.7986