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Comment & Response
March 2016

Potential Benefits of Computer-Aided Detection for Cancer Identification and Treatment—Reply

Author Affiliations
  • 1Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts
JAMA Intern Med. 2016;176(3):411. doi:10.1001/jamainternmed.2015.8474

In Reply Dr Brem believes our findings—that computer-aided detection (CAD) does not improve diagnostic accuracy of mammography—are curious and “incongruent with the overwhelming majority of peer-reviewed, published studies on the topic.” Her perspective is puzzling and ignores the large meta-analysis of 10 CAD studies which found that CAD significantly increased recall rates (and thus false-positive examinations) with no significant improvement in cancer detection rates compared with readings without CAD.1

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