To the Editor The pragmatic, randomized clinical trial of delayed antibiotic prescribing strategies reported by de la Poza Abad and colleagues1 combined antibiotic-inappropriate diagnoses (acute bronchitis) and diagnoses for which antibiotics might be appropriate (rhinosinusitis, pharyngitis). Combining and randomizing patients with diagnoses that should and should not receive antibiotics limits the interpretability and applicability to clinical practice of the trial.
Linder JA, Friedberg MW. Mixed Diagnoses and Mixed Messages. JAMA Intern Med. 2016;176(5):718-719. doi:10.1001/jamainternmed.2016.1284