Endogenous pathologic hypercortisolism, or Cushing syndrome, is associated with poor quality of life, morbidity, and increased mortality.1 The clinical presentation of Cushing syndrome varies, in part related to the extent and duration of cortisol excess.2 When hypercortisolism is severe, its signs and symptoms are unmistakable. In particular, proximal muscle weakness; increased fat in the abdomen, torso, and face; and wide purple striae suggest marked hypercortisolism.
Terrier L, Amelot A, Velut S, François P, Zemmoura I. The Musical Footprint of Cushing Syndrome. JAMA Intern Med. 2016;176(7):1016-1017. doi:10.1001/jamainternmed.2016.2078