Copyright 2016 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
To the Editor In a recent issue of JAMA Internal Medicine, Bischoff-Ferrari and colleagues1 reported the results of an interesting randomized clinical trial testing the efficiency of physiological (equivalence, 800 IU/d) and supraphysiological doses (equivalence, 2000 IU/d or 800 IU/d plus calcifediol 300 μg/mo) of vitamin D supplements in lowering the risk of functional decline. The authors found that older participants in the higher-dose vitamin D groups experienced the greater incidence of falls,1 a result already described with mega doses of vitamin D supplementation2 but in contradiction with the well-recognized antifall effect of physiological doses.3
Annweiler C, Duval G, Launay CP. Estimating Vitamin D Status and the Choice of Supplementation Dose. JAMA Intern Med. 2016;176(6):865. doi:10.1001/jamainternmed.2016.1612