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Comment & Response
Less Is More
June 2016

Estimating Vitamin D Status and the Choice of Supplementation Dose

Author Affiliations
  • 1Division of Geriatric Medicine, Department of Neuroscience, Angers University Hospital, UPRES EA 4638, University of Angers, UNAM, Angers, France
  • 2Service of Geriatric Medicine and Geriatric Rehabilitation, Department of Medicine, Lausanne University Hospital, Switzerland
JAMA Intern Med. 2016;176(6):865. doi:10.1001/jamainternmed.2016.1612

To the Editor In a recent issue of JAMA Internal Medicine, Bischoff-Ferrari and colleagues1 reported the results of an interesting randomized clinical trial testing the efficiency of physiological (equivalence, 800 IU/d) and supraphysiological doses (equivalence, 2000 IU/d or 800 IU/d plus calcifediol 300 μg/mo) of vitamin D supplements in lowering the risk of functional decline. The authors found that older participants in the higher-dose vitamin D groups experienced the greater incidence of falls,1 a result already described with mega doses of vitamin D supplementation2 but in contradiction with the well-recognized antifall effect of physiological doses.3

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