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Comment & Response
June 2016

Adverse Effects of Proton Pump Inhibitors in Chronic Kidney Disease

Author Affiliations
  • 1Clinical Trial Center, Liver Failure Therapy and Research Center, Beijing 302 Hospital (PLA 302 Hospital), Beijing, China
  • 2Division of Pharmacology, Beijing 302 Hospital (PLA 302 Hospital), Beijing, China
  • 3Adverse Drug Reaction Monitoring Center, Beijing 302 Hospital (PLA 302 Hospital), Beijing, China
JAMA Intern Med. 2016;176(6):867. doi:10.1001/jamainternmed.2016.1851

To the Editor We took interest in an article by Lazarus and colleagues published in a recent issue of JAMA Internal Medicine about proton pump inhibitors (PPIs).1 Proton pump inhibitors are common drugs worldwide that are essential for the treatments of gastroesophageal reflux disease, peptic ulcer, and dyspepsia. However, several recent studies reported that PPIs increased the risk of fractures, hypomagnesemia, myocardial infarction, and cryptogenic liver abscess.25 In the article by Lazarus and colleagues,1 the authors examined the association of PPI use and the risk of kidney disease and drew the conclusions that PPI use was associated with a higher risk of incident chronic kidney disease and acute kidney injury.5 Here, we raise some points that should be noted.

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