In Reply The article by Cunningham et al1 and the letter by Kotz et al report on similar topics but come from different research traditions. As such, they serve as a good illustration of the strengths and limitations of randomized clinical trial (RCT) and epidemiological survey research methods and can highlight the synergistic benefits of employing multiple different research methods exploring the same topic.
Cunningham JA. Questioning Nicotine Replacement Therapy Without Behavioral Support—Reply. JAMA Intern Med. 2016;176(6):864-865. doi:10.1001/jamainternmed.2016.1565