Off-label use of antipsychotic medication is increasing, particularly the use of quetiapine for sleep, owing to its sedating properties.1 This is a cause for concern given important adverse effects, including drug-induced diabetes and parkinsonism, weight gain, neuroleptic malignant syndrome, oversedation, and risk of arrhythmia.2 We describe quetiapine use in a prospective cohort of medical inpatients and the proportion of in-hospital use that is perpetuated on discharge.
Lee TC, Desforges P, Murray J, Saleh RR, McDonald EG. Off-label Use of Quetiapine in Medical Inpatients and Postdischarge. JAMA Intern Med. 2016;176(9):1390-1391. doi:10.1001/jamainternmed.2016.3309