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Research Letter
Less Is More
September 2016

Off-label Use of Quetiapine in Medical Inpatients and Postdischarge

Author Affiliations
  • 1Department of Medicine, McGill University, Montreal, Quebec, Canada
  • 2Clinical Practice Assessment Unit, McGill University Health Centre, Montreal, Quebec, Canada
JAMA Intern Med. 2016;176(9):1390-1391. doi:10.1001/jamainternmed.2016.3309

Off-label use of antipsychotic medication is increasing, particularly the use of quetiapine for sleep, owing to its sedating properties.1 This is a cause for concern given important adverse effects, including drug-induced diabetes and parkinsonism, weight gain, neuroleptic malignant syndrome, oversedation, and risk of arrhythmia.2 We describe quetiapine use in a prospective cohort of medical inpatients and the proportion of in-hospital use that is perpetuated on discharge.

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