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Comment & Response
October 2016

Effect of Detecting and Isolating Asymptomatic Clostridium difficile Carriers

Author Affiliations
  • 1Centre for Infectious Diseases, Department of Medical Microbiology, Leiden University Medical Centre, Leiden, the Netherlands
JAMA Intern Med. 2016;176(10):1572-1573. doi:10.1001/jamainternmed.2016.5339

To the Editor The study by Longtin and colleagues1 in a recent issue of JAMA Internal Medicine evaluates the effect of detecting and isolating asymptomatic Clostridium difficile carriers admitted to a 354-bed Canadian tertiary institution in Québec City. The authors found that this approach resulted in a significant decrease of health care-associated C difficile infection (HA-CDI). They also showed a substantial decrease in the proportion of HA-CDI caused by the NAP1/027 strain of C difficile (from 59% to 20%) after implementation of this approach. Although this observation was based on typing of only 86 isolates from their institution over a decade, the decrease was statistically significant, while no concomitant decrease in NAP1/027 was found in other institutions in Québec City.

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