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Comment & Response
October 2016

Effect Of Detecting and Isolating Asymptomatic Clostridium difficile Carriers—Reply

Author Affiliations
  • 1Jewish General Hospital Sir Mortimer B. Davis, Montreal, Canada
  • 2McGill University Faculty of Medicine, Montreal, Canada
  • 3Institut National de Santé Publique du Québec, Quebec City, Canada
  • 4Centre Hospitalier Universitaire de Québec, Québec City, Canada
  • 5Université Laval, Quebec City, Canada
  • 6McGill University Health Centre, Montreal, Canada
JAMA Intern Med. 2016;176(10):1573. doi:10.1001/jamainternmed.2016.5342

In Reply We thank Crobach and colleagues for their thoughtful comments on our article.1 They raise pertinent questions regarding the mechanisms through which the detection and isolation of C difficile carriers on hospital admission could lead to a decrease in Clostridium difficile infection (CDI) rates. They suggest 3 potential mechanisms: a decrease in the progression from carriage to disease; a decrease in spread from carriers; and a decrease in spread from patients with CDI. It is difficult to ascertain which of these mechanisms may have contributed to the decrease in CDI rates in our hospital.

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