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Research Letter
Less Is More
December 2016

Prediabetes Risk in Adult Americans According to a Risk Test

Author Affiliations
  • 1Predictive Analytics and Comparative Effectiveness Center, Tufts Medical Center, Boston, Massachusetts
  • 2Division of Endocrinology, Tufts Medical Center, Boston, Massachusetts
JAMA Intern Med. 2016;176(12):1861-1863. doi:10.1001/jamainternmed.2016.5919

The Diabetes Prevention Program and other studies found that individuals with impaired glucose tolerance (based on a 75-g oral glucose tolerance test) can decrease their risk of type 2 diabetes developing either by an intensive supervised lifestyle intervention, including diet and exercise modification, or by metformin hydrochloride treatment.1,2 Subsequently, the glycemic criteria for prediabetes were expanded to include hemoglobin A1c and a decreased level for fasting glucose.3 Although the benefit of type 2 diabetes prevention is unclear in this broader group, the Centers for Disease Control and Prevention, American Diabetes Association, and American Medical Association have promoted a web-based risk test to evaluate people at high risk for prediabetes for whom they recommend practice-based laboratory testing.4 We estimated the proportion of the adult, nondiabetic US population that would be classified as being at high risk for prediabetes according to this widely endorsed risk instrument.

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