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Comment & Response
December 2016

Low-Density Lipoprotein Levels and Risk of Major Cardiovascular Events—Reply

Author Affiliations
  • 1Clalit Research Institute, Chief Physician's Office, Clalit Health Services, Aviv, Tel Aviv, Israel
  • 2Haifa University, Masa Israel
JAMA Intern Med. 2016;176(12):1876-1877. doi:10.1001/jamainternmed.2016.6871

In Reply We thank Dr Rott for his comments and agree with his concluding statement that guidelines have not and should not be determined by observational studies. They can, however, supplement randomized studies by assessing effects on broader, less rigidly specific populations.1

We also concur that our Original Investigation,2 which focused on the effects in selected patients who were adherent to statins for at least 1 year, does thereby limit the generalizibility of our findings.

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