Passive immunization with human immune globulin (IG) is recommended for prophylaxis against hepatitis A and infection with its causative agent, hepatitis A virus (HAV). Immune globulin preparations administered intramuscularly (0.02 mL/kg) may confer protection for up to 3 months.1 Because anti-HAV antibody levels are declining in plasma donors from developed countries,2 we evaluated antibody levels in currently marketed IG products. Several products had lower-than-expected anti-HAV potencies, potentially conferring protection of reduced magnitude or duration against hepatitis A.
Tejada-Strop A, Costafreda MI, Dimitrova Z, Kaplan GG, Teo C. Evaluation of Potencies of Immune Globulin Products Against Hepatitis A. JAMA Intern Med. 2017;177(3):430-432. doi:10.1001/jamainternmed.2016.9057