In Reply In their Letter to the Editor, Dr Cabrera et al brought up an interesting hypothesis that folic acid fortification might be one of the driving forces for the reversal of the increasing trend in chronic kidney disease (CKD) prevalence during the last 2 decades in Chile and the United States. Although the hypothesis needs further verification, supplementation of folic acid seems to be an effective and inexpensive intervention to reduce the risk of end-stage renal disease.1 Given that folate fortification has not been implemented in most countries of the world,2 this therapy warrants more intensive scrutiny.
Hou FF, Xu X. The Nephroprotective Effect of Folic Acid—Only a Matter of Homocysteine?—Reply. JAMA Intern Med. 2017;177(2):286-287. doi:10.1001/jamainternmed.2016.8593