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Comment & Response
February 2017

The Nephroprotective Effect of Folic Acid—Only a Matter of Homocysteine?—Reply

Author Affiliations
  • 1Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China
  • 2National Clinical Research Center for Kidney Disease, Guangzhou, China
JAMA Intern Med. 2017;177(2):286-287. doi:10.1001/jamainternmed.2016.8593

In Reply In their Letter to the Editor, Dr Cabrera et al brought up an interesting hypothesis that folic acid fortification might be one of the driving forces for the reversal of the increasing trend in chronic kidney disease (CKD) prevalence during the last 2 decades in Chile and the United States. Although the hypothesis needs further verification, supplementation of folic acid seems to be an effective and inexpensive intervention to reduce the risk of end-stage renal disease.1 Given that folate fortification has not been implemented in most countries of the world,2 this therapy warrants more intensive scrutiny.

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