To the Editor In a recent issue of JAMA Internal Medicine, Albrektsen and colleagues1 in a large population-based prospective study found that the risk of myocardial infarction (MI) increased with age in both sexes, with lowest risk for women. This gender gap persisted throughout life, with a diminution of relative risk with age. Furthermore, the female advantage could not be explained by difference in the levels of traditional risk factors for coronary heart disease. However, the role of different body iron stores between sexes was not considered.
Mascitelli L, Goldstein MR. Body Iron Stores and the Gender Gap in Risk of Incident Myocardial Infarction. JAMA Intern Med. 2017;177(4):595. doi:10.1001/jamainternmed.2016.9640